Fenlean

Names

[ Name ]:
Fenlean

Biological Activity

[Description]:

Fenlean, a natural squamosamide derivative, is a Src tyrosine kinase inhibitor. Fenlean can inhibit over-activated microglia and protect dopaminergic neurons. Fenlean can attenuate neuroinflammation in Parkinson's disease models[1][2][3].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

Src tyrosine kinase[1]

[References]

[1]. Tai W, et, al. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology. 2013 Dec;75:201-12.

[2]. Cheng LB, et, al. Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)-AKT signaling. Int J Mol Sci. 2014 Oct 17;15(10):18762-75.

[3]. Ye X, et, al. FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells. Naunyn Schmiedebergs Arch Pharmacol. 2014 Jan;387(1):75-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₇NO₆

[ Molecular Weight ]:
449.50

Related Compounds

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