PTP1B-IN-22

Names

[ CAS No. ]:
86109-60-6

[ Name ]:
PTP1B-IN-22

[Synonym ]:
MFCD00396380
4-{[(1,3-Benzothiazol-2-ylsulfanyl)acetyl]amino}benzoic acid
4-(2-(BENZOTHIAZOL-2-YLSULFANYL)-ACETYLAMINO)-BENZOIC ACID
Benzoic acid, 4-[[2-(2-benzothiazolylthio)acetyl]amino]-

Biological Activity

[Description]:

PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Metabolic Disease

[In Vitro]

PTP1B-IN-22 (compound 3j; 骨骼肌 L6 肌管) 表现出 66.4% 的体外 PTP1B 抑制和 39.6% 的葡萄糖摄取增加[1]。

[References]

[1]. Prashant J, et, al. Molecular modeling and synthesis of ZINC02765569 derivatives as protein tyrosine phosphatase 1B inhibitors: lead optimization study. 2012;22: 1618-23.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C16H12N2O3S2

[ Molecular Weight ]:
344.41

[ Exact Mass ]:
344.028931

[ LogP ]:
4.33

[ Index of Refraction ]:
1.741

Related Compounds