cGAS-IN-1

Names

[ CAS No. ]:
858770-07-7

[ Name ]:
cGAS-IN-1

Biological Activity

[Description]:

cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

IC50: 2.28 μM (human cGAS); 1.44 μM (mouse cGAS)[1]


[References]

[1]. Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19NO8

[ Molecular Weight ]:
377.35

Related Compounds