858770-07-7

858770-07-7 structure

Name: cGAS-IN-1
Chemical Name: cGAS-IN-1
CAS Number: 858770-07-7
Molecular Formula: C₁₈H₁₉NO₈
Molecular Weight: 377.35
Catalog: Research Areas Inflammation/Immunology
Create Date: 2024-07-17 15:24:33
Modify Date: 2024-07-17 15:24:33
cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1].

Name	cGAS-IN-1

Description	cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	IC50: 2.28 μM (human cGAS); 1.44 μM (mouse cGAS)[1]
References	[1]. Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .

Molecular Formula	C₁₈H₁₉NO₈
Molecular Weight	377.35