Vialinin A

Names

[ Name ]:
Vialinin A

[Synonym ]:
5',6'-bis(phenylacetoxy)-1,1':4',1''-terphenyl-2',3',4,4''-tetraol
Vialinin A
terrestrin A
4,5',6',4''-tetrahydroxy-2',3'-di(phenylacetoxy)-[1,1',4',1''-terphenyl]
4,4'',5',6'-Tetrahydroxy-1,1':4',1''-terphenyl-2',3'-diyl bis(phenylacetate)
Benzeneacetic acid, 4,4'',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl ester

Biological Activity

[Description]:

Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties[1]. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A (Terrestrin A) can be used for autoimmune diseases and cancer research[2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

Research Areas >> Inflammation/Immunology

[References]

[1]. Ji-Kai Liu, et al. Natural terphenyls: developments since 1877. Chem Rev. 2006 Jun;106(6):2209-23.

[2]. Jie Xu, et al. Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.J Cell Mol Med. 2021 Jan;25(2):1140-1150.

[3]. Himangshu Sonowal,et al. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxid Med Cell Longev. 2018 Feb 6;2018:1052102.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
846.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₂₆O₈

[ Molecular Weight ]:
562.57

[ Flash Point ]:
277.1±27.8 °C

[ Exact Mass ]:
562.162781

[ PSA ]:
133.52000

[ LogP ]:
4.58

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.677

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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