DNP-PEG4-acid

Names

[ Name ]:
DNP-PEG4-acid

[Synonym ]:
DNP-PEG4-ACID
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[(2,4-dinitrophenyl)amino]-
DNP-NH-PEG(4)-COOH 1-(2,4-DINITROPHENYLAMINO)-3,6,9,12-TETRAOXAPENTADECANOIC ACID

Biological Activity

[Description]:

DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₅N₃O₁₀

[ Molecular Weight ]:
431.39500

[ Exact Mass ]:
431.15400

[ PSA ]:
177.89000

[ LogP ]:
2.57540

DNP-PEG4-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds