858126-76-8

858126-76-8 structure

Name: DNP-PEG4-acid
Chemical Name: Propanoic acid, 3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]
CAS Number: 858126-76-8
Molecular Formula: C₁₇H₂₅N₃O₁₀
Molecular Weight: 431.39500
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-09-28 05:48:57
Modify Date: 2024-01-08 18:16:43
DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Propanoic acid, 3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]
Synonyms	DNP-PEG4-ACID 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[(2,4-dinitrophenyl)amino]- DNP-NH-PEG(4)-COOH 1-(2,4-DINITROPHENYLAMINO)-3,6,9,12-TETRAOXAPENTADECANOIC ACID

Description	DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562