TP-051

Names

[ CAS No. ]:
858097-86-6

[ Name ]:
TP-051

Biological Activity

[Description]:

TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR40
Research Areas >> Metabolic Disease

[Target]

Ki: 16 nM (human FFAR1)[1]


[In Vitro]

TP-051 (compound 31) (0.01-10 μM; 2 h; INS-1 cells) augments insulin secretion in a dose-dependent manner in the presence of 11 mM glucose and statistically significant increases in insulin secretion were observed at doses of above 0.1 μM of the compound[1].

[References]

[1]. Mikami S, et al. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem. 2012 Apr 26;55(8):3756-76.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H31FO6S

[ Molecular Weight ]:
526.62

Related Compounds