858097-86-6

858097-86-6 structure

858097-86-6 structure

Name: TP-051
Chemical Name: TP-051
CAS Number: 858097-86-6
Molecular Formula: C₂₉H₃₁FO₆S
Molecular Weight: 526.62
Catalog: Signaling Pathways GPCR/G Protein GPR40
Create Date: 2022-11-14 22:58:57
Modify Date: 2024-01-06 16:23:00
TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1].

Name	TP-051

Description	TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
Target	Ki: 16 nM (human FFAR1)[1]
In Vitro	TP-051 (compound 31) (0.01-10 μM; 2 h; INS-1 cells) augments insulin secretion in a dose-dependent manner in the presence of 11 mM glucose and statistically significant increases in insulin secretion were observed at doses of above 0.1 μM of the compound[1].
References	[1]. Mikami S, et al. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem. 2012 Apr 26;55(8):3756-76.

Molecular Formula	C₂₉H₃₁FO₆S
Molecular Weight	526.62