Kurarinol

Names

[ Name ]:
Kurarinol

Biological Activity

[Description]:

Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

IC50: 0.1 μM (mushroom tyrosinase)[1]

[In Vitro]

Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1]. Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1]. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2].

[In Vivo]

Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3]. Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3] Dosage: 20 mg/kg Administration: Oral administration, daily, for 3 days Result: Decreased serum TC, TG, and LDL-C levels.

[References]

[1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8.

[2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65.

[3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₂O₇

[ Molecular Weight ]:
456.52800

[ Exact Mass ]:
456.21500

[ PSA ]:
116.45000

[ LogP ]:
4.80440