Name | kurarinol |
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Description | Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1]. |
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Related Catalog | |
Target |
IC50: 0.1 μM (mushroom tyrosinase)[1] |
In Vitro | Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1]. Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1]. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2]. |
In Vivo | Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3]. Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3] Dosage: 20 mg/kg Administration: Oral administration, daily, for 3 days Result: Decreased serum TC, TG, and LDL-C levels. |
References |
Molecular Formula | C26H32O7 |
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Molecular Weight | 456.52800 |
Exact Mass | 456.21500 |
PSA | 116.45000 |
LogP | 4.80440 |