Adenosine,8-chloro-2'-deoxy- (9CI)

Names

[ Name ]:
Adenosine,8-chloro-2'-deoxy- (9CI)

[Synonym ]:
8-Chloro-2'-deoxy-D-adenosine
8-CL-DADO

Biological Activity

[Description]:

8-Chloro-2'-deoxyadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

Chemical & Physical Properties

[ Density]:
2.03g/cm3

[ Boiling Point ]:
660ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂ClN₅O₄

[ Molecular Weight ]:
301.69

[ Flash Point ]:
353ºC

[ Exact Mass ]:
285.06300

[ PSA ]:
119.31000

[ LogP ]:
0.28380

[ Index of Refraction ]:
1.87

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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