HLY78

Names

[ Name ]:
HLY78

[Synonym ]:
4-ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
4-Aethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridin

Biological Activity

[Description]:

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Wnt

Research Areas >> Neurological Disease

[Target]

Wnt/β-catenin[1]

[References]

[1]. Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇NO₂

[ Molecular Weight ]:
267.32200

[ Exact Mass ]:
267.12600

[ PSA ]:
21.70000

[ LogP ]:
3.65950

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
N

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds

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