Indirubin E804

E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R

Research Areas >> Cancer

Research Areas >> Others

IC50: 0.65 μM (IGF1R)[1].

Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1].

[1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962.

OSI-906(Linsitinib) | BMS-754807 | Picropodophyllotoxin | NVP-AEW541 | BMS-536924 | AZD-3463 | XL228 | GSK1838705A | NVP-ADW742 | AG-1024 | Ginsenoside Rg5 | PQ 401 | GSK1904529A