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Flt-3 Inhibitor III

Names

[ CAS No. ]:
852045-46-6

[ Name ]:
Flt-3 Inhibitor III

[Synonym ]:
FLT3 Inhibitor III
2-Thiazolamine, 5-phenyl-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
5-Phenyl-N-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1,3-thiazol-2-amine
Flt-3 Inhibitor III

Biological Activity

[Description]:

Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[Target]

IC50: 50 nM (FLT3 kinase)[1]


[In Vitro]

Flt-3 Inhibitor III（化合物 4）也抑制 c-Kit、KDR、c-Abl、CDK1、c-Src 和 Tie-2，IC50 值分别为 0.26 µM、0.91 µM、1.2 µM、2.1 µM、2.8 µM 和 8.0 µM[1]。 Flt-3 Inhibitor III（化合物 4）阻断 BaF3-ITD、BaF3-D835/Y 和 MV4:11 细胞的增殖，IC50 值分别为 0.24 µM、0.76 µM 和 0.052 µM[1] 。

[References]

[1]. Pascal Furet, et al. Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J Med Chem. 2006 Jul 27;49(15):4451-4.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
554.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H23N3OS

[ Molecular Weight ]:
365.492

[ Flash Point ]:
288.9±32.9 °C

[ Exact Mass ]:
365.156189

[ LogP ]:
4.48

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.640

Safety Information

Related Compounds