RuBi-4AP

Names

[ CAS No. ]:
851956-02-0

[ Name ]:
RuBi-4AP

[Synonym ]:
(S)-(-)-2-Amino-3-(3-indolyl)propionic Acid

Biological Activity

[Description]:

RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Zayat L, et al. A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage. J Am Chem Soc. 2003 Jan 29;125(4):882-3.

[2]. Rowan MJ, et al. Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. J Neurosci. 2014 May 7;34(19):6611-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₂₈Cl₂N₈Ru

[ Molecular Weight ]:
672.57

[ Exact Mass ]:
204.09000

[ PSA ]:
79.11000

[ LogP ]:
1.82260

Related Compounds

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