RuBi-4AP

RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation[1][2].

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[1]. Zayat L, et al. A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage. J Am Chem Soc. 2003 Jan 29;125(4):882-3.  

[2]. Rowan MJ, et al. Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. J Neurosci. 2014 May 7;34(19):6611-23.