(S)-4-BENZYL-1,3-THIAZOLIDINE-2-ONE

Names

[ Name ]:
(S)-4-BENZYL-1,3-THIAZOLIDINE-2-ONE

[Synonym ]:
Tocris-0320
trans-Triprolidine hydrochloride

Biological Activity

[Description]:

(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. C Thomsen, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62(6):2492-5.

[2]. Thomsen C, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62(6):2492-5.

Chemical & Physical Properties

[ Density]:
1.596g/cm3

[ Boiling Point ]:
479.1ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₉NO₅

[ Molecular Weight ]:
211.17100

[ Flash Point ]:
243.6ºC

[ Exact Mass ]:
211.04800

[ PSA ]:
120.85000

[ LogP ]:
0.87510

[ Index of Refraction ]:
1.675

Safety Information

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%