LJ 001

Names

[ Name ]:
LJ 001

[Synonym ]:
(5Z)-3-Allyl-5-[(5-phenyl-2-furyl)methylene]-2-thioxo-1,3-thiazolidin-4-one
(5Z)-5-[(5-phenylfuran-2-yl)methylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
8646IPJ1AP
4-Thiazolidinone, 5-[(5-phenyl-2-furanyl)methylene]-3-(2-propen-1-yl)-2-thioxo-, (5Z)-
LJ-001

Biological Activity

[Description]:

LJ 001 ((LJ-001, LJ001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1; specifically intercalates into viral membranes, irreversibly inactivates virions while leaving functionally intact envelope proteins, and inhibits viral entry at a step after virus binding but before virus-cell fusion; specifically inhibits virus-cell but not cell-cell fusion

[References]

References 1. Wolf MC, et al. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62. 2. Vigant F, et al. PLoS Pathog. 2013;9(4):e1003297. 3. Balmer BF, et al. J Virol. 2017 Jan 31;91(4). pii: e02181-16. View Related Products by Target Influenza Virus

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
477.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₃NO₂S₂

[ Molecular Weight ]:
327.421

[ Flash Point ]:
242.5±31.5 °C

[ Exact Mass ]:
327.038757

[ LogP ]:
4.14

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.705

Related Compounds

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