(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one

Names

[ Name ]:
(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one

[Synonym ]:
(3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-, (3R)-

Biological Activity

[Description]:

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vitro]

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI50 value of 35.8 µM on proliferation of human retinal microvascular endothelial cells (HRECs)[1]. (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 µM, 30 µM, and 100 µM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner[1].

[References]

[1]. Sianne L Schwikkard, et al. Antiangiogenic Activity and Cytotoxicity of Triterpenoids and Homoisoflavonoids from Massonia pustulata and Massonia bifolia. Planta Med. 2018 Jul;84(9-10):638-644.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
574.8±39.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄O₅

[ Molecular Weight ]:
286.279

[ Flash Point ]:
220.0±20.6 °C

[ Exact Mass ]:
286.084137

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.684

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.