TPI 287

Names

[ Name ]:
TPI 287

[Synonym ]:
Hexanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-5-methyl-, (1S,2S,4S,7S,7aR,10aS,11aR,13aS,13bR,13cS)-7,13a-bis(acetyloxy)-1-(benzoyloxy)-9-ethenyl-1,3,4,7,7a,10a,11,11a,13,13a,13b,13c-dodecahydro-2-hydroxy-5,13c,14,14-tetramethyl-2,6-methano-2H-cyclodec[de]oxeto[3,2-g][1,3]benzodioxin-4-yl ester, (2R,3S)-
TPI-287
(1R,2S,5R,7S,11R,12S,15S,17S,18S,19S)-2,12-Diacetoxy-17-hydroxy-15-{[(2R,3S)-2-hydroxy-5-methyl-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)hexanoyl]oxy}-14,19,20,20-tetramethyl-9-vinyl-4,8,10-trioxa ;pentacyclo[9.7.1.1.0.0]icos-13-en-18-yl benzoate

Biological Activity

[Description]:

TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[In Vivo]

TPI-287 (i.v., 18 mg/kg, every 4 days, 41 days) 在接种了 231-BR 乳腺癌细胞的小鼠肿瘤模型中，可以有效减小肿瘤体积，抑制肿瘤的生长[1]。

[References]

[1]. Daniel P Fitzgerald, et al. TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11(9):1959-67.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
857.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₆H₆₃NO₁₅

[ Molecular Weight ]:
869.990

[ Flash Point ]:
472.3±34.3 °C

[ Exact Mass ]:
869.419800

[ PSA ]:
211.68000

[ LogP ]:
7.97

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.573

Related Compounds

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