Ritipenem

Names

[ CAS No. ]:
84845-57-8

[ Name ]:
Ritipenem

[Synonym ]:
ritipenem acoxil

Chemical & Physical Properties

[ Density]:
1.71g/cm3

[ Boiling Point ]:
659.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂N₂O₆S

[ Molecular Weight ]:
288.27700

[ Flash Point ]:
352.6ºC

[ Exact Mass ]:
288.04200

[ PSA ]:
155.46000

[ Index of Refraction ]:
1.691

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0191750

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)- 6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-

CAS REGISTRY NUMBER :: 84845-57-8

LAST UPDATED :: 199606

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-N2-O6-S

MOLECULAR WEIGHT :: 288.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in potassium

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 29,3475,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3500 mg/kg/7D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in chlorine

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 29,3475,1995

Synthetic Route

Click to get detail synthetic route

Related Compounds

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