Fluorofenidone

Names

[ Name ]:
Fluorofenidone

[Synonym ]:
fluorofenidone

Biological Activity

[Description]:

Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[References]

[1]. Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9.

[2]. Lou Q, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₀FNO

[ Molecular Weight ]:
203.21200

[ Exact Mass ]:
203.07500

[ PSA ]:
22.00000

[ LogP ]:
2.28500

Related Compounds

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