Acetoxyvalerenic acid

Names

[ Name ]:
Acetoxyvalerenic acid

[Synonym ]:
ACETOXYVALERENIC ACID
1-ACETOXYVALERENIC ACID
2-Propenoic acid, 3-[1-(acetyloxy)-2,4,5,6,7,7a-hexahydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-, [1R-[1α,4α(E),7β,7aα]]-
Valerenolic acid, acetyl-
Acetoxyvalerenic acid
Acetylvalerenolic acid

Biological Activity

[Description]:

Acetoxyvalerenic acid is a natural compound that could be found in valerian[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Acetoxyvalerenic acid (AVA, 2 μM) and is most efficient in enhancing IGABA (183.1 ± 24.8 %)[1].

[References]

[1]. Gabriele Trauner, et al. Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta Med. 2008 Jan;74(1):19-24.

[2]. Tania Lefebvre, et al. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharm Sci. 2004 Aug 12;7(2):265-73.

Chemical & Physical Properties

[ Density]:
1.31 g/cm3

[ Molecular Formula ]:
C₁₇H₂₄O₄

[ Molecular Weight ]:
292.37000

[ Exact Mass ]:
292.16700

[ PSA ]:
63.60000

[ LogP ]:
3.33150

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Esters of valerenic acid as potential prodrugs.

Eur. J. Pharmacol. 735 , 123-31, (2014)

Valerenic acid (VA) is a β2/3 subunit-specific modulator of γ-aminobutyric acid (GABA) type A (GABAA) receptors inducing anxiolysis. Here we analyze if VA-esters can serve as prodrugs and if different...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.