tris succinate

Names

[ Name ]:
tris succinate

[Synonym ]:
TRIS(HYDROXYMETHYL)AMINOMETHANE SUCCINATE
TRIS-SUCCINATE
succinic acid,compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)
TRIZMA SUCCINATE
DI[TRIS(HYDROXYMETHYL)AMINOMETHANE] SUCCINATE
2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL SUCCINATE

Biological Activity

[Description]:

Succinic acid tromethamine is a potent and orally active anxiolytic agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Microbial Metabolite

Human Endogenous Metabolite

[In Vitro]

Succinic acid tromethamine is derived from the fermentation of agricultural carbohydrates[2].

[In Vivo]

Succinic acid tromethamine (3, 6 mg/kg; p.o.) increases the percentage of entries into open arms and of time spent on open arms in male mice[3]. Succinic acid tromethamine (3, 6, 12 mg/kg; i.p.) significant increases in food intake during 5 min, and 40 min after drug administration rectal temperature was measured, succinic acid at a dose of 1.5 mg/kg, inhibited stress-induced hyperthermia[3].

[References]

[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10.

[2]. A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 1948;42(1):ii.

[3]. Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64.