XENALIPIN

Names

[ Name ]:
XENALIPIN

[Synonym ]:
XENALIPIN
4'-(Trifluoromethyl)-2-biphenylcarboxylic acid
4'-(trifluoromethyl)biphenyl-2-carboxylic acid
2-[4-(trifluoromethyl)phenyl]benzoic acid
MFCD00075353
[1,1'-Biphenyl]-2-carboxylic acid, 4'-(trifluoromethyl)-
4'-(Trifluoromethyl)-1,1'-biphenyl-2-carboxylic Acid
4-(Trifluoromethyl)-2'-biphenylcarboxylic acid

Biological Activity

[Description]:

4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

4'-Trifluoromethyl-2-biphenyl carboxylic acid (15-60 mg/kg, p.o., twice a day) shows hypolipidemic activity in diet-induced hypercholesterolemic African green monkeys[1]. Animal Model: Diet-induced hypercholesterolemic African green monkeys[5] Dosage: 15-60 mg/kg Administration: Oral administration (p.o.) Result: Reduced serum LDL-cholesterol concentrations.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
335.8±37.0 °C at 760 mmHg

[ Melting Point ]:
169-171 °C(lit.)

[ Molecular Formula ]:
C₁₄H₉F₃O₂

[ Molecular Weight ]:
266.215

[ Flash Point ]:
156.9±26.5 °C

[ Exact Mass ]:
266.055450

[ PSA ]:
37.30000

[ LogP ]:
3.97

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Evaluation of the hypolipidemic activity of xenalipin in experimental animals.

Atherosclerosis 64(1) , 27-35, (1987)

Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in ser...

The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin. Eaddy JF.

Org. Prep. Proced. Int. 27(3) , 367-72, (1995)

Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent. Hill JA and Eaddy JF.

J. Labelled Comp. Radiopharm. 31(12) , 1011-17, (1992)

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.