Wilforlide A

Names

[ Name ]:
Wilforlide A

[Synonym ]:
Olean-12-en-29-one, 22,29-epoxy-3-hydroxy-, (3β,22α)-
WOLFORLIDE A
(3β,22α)-3-Hydroxy-22,29-epoxyolean-12-en-29-one
Regelide
Wilforlide
WilforlideA
abruslactone A

Biological Activity

[Description]:

Wilforlide A is a natural product, separated from the ethanolic extract of tripterygium wilfordii. IC50 value:Target:In vitro:In vivo: Carrageenan-induced rat pedal swelling, tampon-induced rat granulation, and mice ear inhibition rate of swelling trail results show that high-dose wilforlide A has obvious anti-inflammatory effect, but has no significant immune suppressive activity [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Terpenoids and Glycosides

Research Areas >> Inflammation/Immunology

[References]

[1]. Mei Xue, et al. Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A. Fitoterapia Volume 81, Issue 8, December 2010, Pages 1109–1112

[2]. HU Jian-lin, et al. Determination of Wilforlide A in Tripterygium hypoglaucum (Levl.) Hutch by HPLC. Journal of Kunming Medical College, 2010-07

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
555.0±50.0 °C at 760 mmHg

[ Melting Point ]:
318 °C

[ Molecular Formula ]:
C₃₀H₄₆O₃

[ Molecular Weight ]:
454.684

[ Flash Point ]:
208.6±22.9 °C

[ Exact Mass ]:
454.344696

[ PSA ]:
46.53000

[ LogP ]:
7.47

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.563

Safety Information

[ Hazard Codes ]:
C

Precursor & DownStream

Precursor

DownStream

Related Compounds

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