Lumirubin

Names

[ Name ]:
Lumirubin

[Synonym ]:
Lumirubin IX

Biological Activity

[Description]:

Lumirubin, a structural isomer of bilirubin, is the main photooxidative product formed during phototherapy for the treatment of neonatal jaundice, and has a certain pro-inflammatory effect[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Lumirubin (25 μmol/L, 4 h) 可以持续增加 CNS 细胞中促炎基因、TNF-α、IL-1β、IL-6 和环加氧酶-2 (COX-2) 的表达，导致器官型大鼠海马切片中 TNF-α 产量急剧增加[1]。

[References]

[1]. J Jašprová, et al. Neuro-inflammatory effects of photodegradative products of bilirubin. Sci Rep. 2018 May 10;8(1):7444.

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Molecular Formula ]:
C₃₃H₃₆N₄O₆

[ Molecular Weight ]:
584.66200

[ Exact Mass ]:
584.26300

[ PSA ]:
164.44000

[ LogP ]:
4.45600

[ Index of Refraction ]:
1.672

Related Compounds

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