10-HYDROXYWARFARIN

[ Density]:
1.388 g/cm3

[ Boiling Point ]:
509.2ºC at 760 mmHg

[ Melting Point ]:
183-185ºC

[ Molecular Formula ]:
C₁₉H₁₆O₅

[ Molecular Weight ]:
324.32700

[ Flash Point ]:
185ºC

[ Exact Mass ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
2.58040

[ Index of Refraction ]:
1.656

Click to get detail MSDS

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H318

[ Precautionary Statements ]:
P264-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
25-41

[ Safety Phrases ]:
26-39-45

[ RIDADR ]:
UN 2811 6

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

J. Chromatogr. A. 1363 , 200-6, (2014)

Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase...

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.

Drug Metab. Lett. 4(4) , 213-9, (2010)

Effective coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and ...

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