AC 1903

Names

[ Name ]:
AC 1903

[Synonym ]:
1H-Benzimidazol-2-amine, N-(2-furanylmethyl)-1-(phenylmethyl)-
MFCD06609959
1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine

Biological Activity

[Description]:

AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM; blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)-induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations; pecifically blocks TRPC5 channel activity in glomeruli of proteinuric rats, suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of FSGS.

[References]

References 1. Zhou Y, et al. Science. 2017 Dec 8;358(6368):1332-1336. View Related Products by Target TRP Channel

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
512.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₇N₃O

[ Molecular Weight ]:
303.358

[ Flash Point ]:
263.7±32.9 °C

[ Exact Mass ]:
303.137177

[ LogP ]:
4.23

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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