4-chloro-2,8-di(trifluoromethyl)quinoline

Names

[ Name ]:
4-chloro-2,8-di(trifluoromethyl)quinoline

[Synonym ]:
4-chloro-2,8-di(trifluoromethyl)quinoline
4-Chloro-2,8-bis(trifluoromethyl)quinoline
EINECS 280-132-5
MFCD00075104
4-Chloro-2,8-bis-trifluoromethyl-quinoline
Quinoline, 4-chloro-2,8-bis(trifluoromethyl)-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
251.8±35.0 °C at 760 mmHg

[ Melting Point ]:
46-48 °C(lit.)

[ Molecular Formula ]:
C₁₁H₄ClF₆N

[ Molecular Weight ]:
299.600

[ Flash Point ]:
106.1±25.9 °C

[ Exact Mass ]:
298.993652

[ PSA ]:
12.89000

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.495

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

New quinoline derivatives: synthesis and investigation of antibacterial and antituberculosis properties.

Eur. J. Med. Chem. 45 , 3374, (2010)

Four new series of quinoline derivatives were synthesized starting from 2-trifluoromethyl aniline through multi-step reactions. In the reaction sequence, substituted aniline was cyclized to 4-hydroxy ...