Skimmianin

Names

[ CAS No. ]:
83-95-4

[ Name ]:
Skimmianin

[Synonym ]:
skimmiamine
7,8-Dimethoxydictamnine
Skimmianine
b-fagarine
β-Fagarine
Chloroxylonine
4,7,8-Trimethoxyfuro[2,3-b]quinoline
Skimmianin
Furo[2,3-b]quinoline, 4,7,8-trimethoxy-

Biological Activity

[Description]:

Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with analgesic, antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Huang A, et al. Metabolic Profile of Skimmianine in Rats Determined by Ultra-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. Molecules. 2017 Mar 23;22(4).

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
401.6±40.0 °C at 760 mmHg

[ Melting Point ]:
178°

[ Molecular Formula ]:
C₁₄H₁₃NO₄

[ Molecular Weight ]:
259.257

[ Flash Point ]:
196.7±27.3 °C

[ Exact Mass ]:
259.084473

[ PSA ]:
53.72000

[ LogP ]:
2.86

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.621

[ Storage condition ]:
2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV2800000

CHEMICAL NAME :: Furo(2,3-b)quinoline, 4,7,8-trimethoxy-

CAS REGISTRY NUMBER :: 83-95-4

BEILSTEIN REFERENCE NO. :: 0028904

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H13-N-O4

MOLECULAR WEIGHT :: 259.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 5 ug/plate

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 34,1826,1986

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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