2,3-Dihydroisoginkgetin

Names

[ Name ]:
2,3-Dihydroisoginkgetin

[Synonym ]:
4H-1-Benzopyran-4-one, 2-[3-[5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-4-methoxyphenyl]-2,3-dihydro-5,7-dihydroxy-, (2S)-
8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2-methoxyphenyl}-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

Biological Activity

[Description]:

2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC50 of 86.16 μM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[References]

[1]. Cheng KT, et al. New constituent from Podocarpus macrophyllus var. macrophyllus shows anti-tyrosinase effect and regulates tyrosinase-related proteins and mRNA in human epidermal melanocytes. Chem Pharm Bull (Tokyo). 2007 May;55(5):757-61.

Chemical & Physical Properties

[ Density]:
1.5±0.0 g/cm3

[ Boiling Point ]:
850.6±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₂₄O₁₀

[ Molecular Weight ]:
568.527

[ Flash Point ]:
281.8±0.0 °C

[ Exact Mass ]:
568.137024

[ PSA ]:
155.89000

[ LogP ]:
5.94

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.695

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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