Asp-AMS

Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.

Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism

Research Areas >> Metabolic Disease

Aspartyl-tRNA synthetase, Mitochondrial enzyme [1].

Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with Ki in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with Ki values in the nanomolar range, with a stronger effect on bacterial AspRSs (E. coli and P. aeruginosa) than on human cytosolic AspRS[1].

[1]. Messmer M, et al. Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie. 2009 May;91(5):596-603.

Rotenone | FCCP | Elamipretide | NIM811 | Daidzin | TRO 19622 | Imeglimin hydrochloride | α-Lipoic Acid | Mitochonic acid 5 | ER-000444793 | Mito-TEMPO | Leu-AMS | Aminoacyl tRNA synthetase-IN-1 | lipoic acid | Adjudin