828288-98-8

828288-98-8 structure

Name: Asp-AMS
Chemical Name: Asp-AMS
CAS Number: 828288-98-8
Molecular Formula: C₁₄H₁₉N₇O₉S
Molecular Weight: 461.41
Catalog: Signaling Pathways Metabolic Enzyme/Protease Mitochondrial Metabolism
Create Date: 2019-01-20 03:21:17
Modify Date: 2024-01-09 17:53:28
Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.

Name	Asp-AMS

Description	Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism Research Areas >> Metabolic Disease
Target	Aspartyl-tRNA synthetase, Mitochondrial enzyme [1].
In Vitro	Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with Ki in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with Ki values in the nanomolar range, with a stronger effect on bacterial AspRSs (E. coli and P. aeruginosa) than on human cytosolic AspRS[1].
References	[1]. Messmer M, et al. Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie. 2009 May;91(5):596-603.