2-Hydroxyethyl acrylate
Names
[ CAS No. ]:
818-61-1
[ Name ]:
2-Hydroxyethyl acrylate
[Synonym ]:
2-Propenoic acid, 2-hydroxyethyl ester
bisomer2hea
2-Hydroxyethyl acryl
Hydroxyethyl acrylate
HEA
ethylene glycol monoacrylate
methanol,methyl acrylate
2-hydroxyethyl prop-2-enoate
acrylic acid 2-hydroxy-ethyl ester
4-acryloyloxyethyl alcohol
EINECS 212-454-9
2-Hydroxyethylacrylat
MFCD00002865
2-Hydroxyethyl acrylate
Glycolmonoacrylate
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
196.2±23.0 °C at 760 mmHg
[ Melting Point ]:
-60 °C
[ Molecular Formula ]:
C5H8O3
[ Molecular Weight ]:
116.115
[ Flash Point ]:
98.3±0.0 °C
[ Exact Mass ]:
116.047340
[ PSA ]:
46.53000
[ LogP ]:
-0.05
[ Vapour density ]:
>1 (vs air)
[ Vapour Pressure ]:
0.1±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.440
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AT1750000
- CHEMICAL NAME :
- Acrylic acid, 2-hydroxyethyl ester
- CAS REGISTRY NUMBER :
- 818-61-1
- BEILSTEIN REFERENCE NO. :
- 0969853
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C5-H8-O3
- MOLECULAR WEIGHT :
- 116.13
- WISWESSER LINE NOTATION :
- Q2OV1U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 650 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - convulsions or effect on seizure threshold Gastrointestinal - alteration in gastric secretion
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1010 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 38500 ug/m3/9W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Cardiac - EKG changes not diagnostic of specified effects Endocrine - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3900 mg/kg/13W-I
- TOXIC EFFECTS :
- Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38500 ug/m3/9W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Cardiac - EKG changes not diagnostic of specified effects Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 15 mg/L
- REFERENCE :
- MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,381,1989 *** REVIEWS *** TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,141,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1326 No. of Facilities: 63 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 1845 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1326 No. of Facilities: 107 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 2370 (estimated) No. of Female Employees: 354 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H311-H314-H317-H400
[ Precautionary Statements ]:
P273-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P333 + P313
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R20/22;R24;R34;R43;R50
[ Safety Phrases ]:
S26-S36/39-S45-S61-S36/37/39
[ RIDADR ]:
UN 2927 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
AT1750000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2916129000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2916129000
[ Summary ]:
2916129000 other esters of acrylic acid VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
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Anisotropy is one of the most meaningful determinants of biomechanical behaviour. This study employs micro-computed tomography (μCT) and image techniques for analysing the anisotropy of regenerative m...
Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers.Neurosci. Lett. 598 , 96-101, (2015)
The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an...
Photopatterned oil-reservoir micromodels with tailored wetting properties.Lab Chip 15 , 3047-55, (2015)
Micromodels with a simplified porous network that represents geological porous media have been used as experimental test beds for multiphase flow studies in the petroleum industry. We present a new me...