<Suppliers Price>

NSC348884

Names

[ CAS No. ]:
81624-55-7

[ Name ]:
NSC348884

[Synonym ]:
N,N,N',N'-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine
1,2-Ethanediamine, N,N,N,N-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-
NSC348884

Biological Activity

[Description]:

NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1]

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20.


[Related Small Molecules]

Epibrassinolide | Elesclomol(STA-4783) | Adarotene | Myricetin | sanguinarium chloride | Betulinic acid | Taurochenodeoxycholic acid | Baohuoside I | Costunolide | 20(S)-Ginsenoside Rh2 | Betulin | Polydatin | SMIP004 | G5 | 6-Gingerol

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1001.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C38H40N10

[ Molecular Weight ]:
636.791

[ Flash Point ]:
559.6±34.3 °C

[ Exact Mass ]:
636.343750

[ PSA ]:
121.20000

[ LogP ]:
4.74

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.768

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream