<Suppliers Price>

NSC348884

Names

[ CAS No. ]:
81624-55-7

[ Name ]:
NSC348884

[Synonym ]:
N,N,N',N'-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine
1,2-Ethanediamine, N,N,N,N-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-
NSC348884

Biological Activity

[Description]:

NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1]

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20.


[Related Small Molecules]

Epibrassinolide | Elesclomol(STA-4783) | Adarotene | Myricetin | sanguinarium chloride | Betulinic acid | Taurochenodeoxycholic acid | Baohuoside I | Costunolide | 20(S)-Ginsenoside Rh2 | Betulin | Polydatin | SMIP004 | G5 | 6-Gingerol

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1001.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C38H40N10

[ Molecular Weight ]:
636.791

[ Flash Point ]:
559.6±34.3 °C

[ Exact Mass ]:
636.343750

[ PSA ]:
121.20000

[ LogP ]:
4.74

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.768

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.