81624-55-7

81624-55-7 structure

Name: NSC348884
Chemical Name: N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine
CAS Number: 81624-55-7
Molecular Formula: C₃₈H₄₀N₁₀
Molecular Weight: 636.791
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-31 13:01:27
Modify Date: 2024-01-11 01:00:49
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1]

Name	N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine
Synonyms	N,N,N',N'-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine 1,2-Ethanediamine, N,N,N,N-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]- NSC348884

Description	NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1]
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20.

60-00-4

496-72-0

81624-55-7

Literature: US2008/221146 A1, ; Page/Page column 7-8 ;

Precursor 2
60-00-4 496-72-0
DownStream 0