Momordicoside L

Names

[ Name ]:
Momordicoside L

[Synonym ]:
3-hydroxy-17-(5-hydroxy-1,5-dimethyl-hex-3-enyl)-4,4,13,14-tetramethyl-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-1,2,3,4,7,8,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-9-carbaldehyde
3β,25-dihydroxy-19-oxo-cucurbita-5,23-diene-7β-yl β-D-glucopyranoside
momordicoside K
momordicoside L

Biological Activity

[Description]:

Momordicoside L is a Cucurbitane Triterpenoid, that can be isolated from the leaves of Momordica charantia. Momordicoside L shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Momordicoside L 对 HL60（白血病）、CRL1579（黑色素瘤）、A549（肺）、SK-BR-3（乳腺）和 AZ521（胃）细胞显示出中度细胞毒性，IC50 值分别为 37.2 ± 2.7、11.9 ± 2.2、>50、>50 和 19.9 ± 1.5 μM[1]。

[References]

[1]. Zhang J, et al. Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities. Chem Biodivers. 2012 Feb;9(2):428-40.

Chemical & Physical Properties

[ Density]:
1.24±0.1 g/cm3

[ Boiling Point ]:
756.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₅₈O₉

[ Molecular Weight ]:
634.84000

[ Exact Mass ]:
634.40800

[ PSA ]:
156.91000

[ LogP ]:
3.27980

Related Compounds

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