Boc-L-glutamic acid 1-benzyl ester

Names

[ Name ]:
Boc-L-glutamic acid 1-benzyl ester

[Synonym ]:
N-α-tert-BOC-L-glutamic-γ-benzyl ester
Boc-L-glutamic acid 1-benzyl ester
(2S)-5-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-5-oxopentanoic acid (non-preferred name)
Boc-Glu-OBzl
5-Benzyl N-(tert-Butoxycarbonyl)-L-glutamate
L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-(phenylmethyl) ester
Boc-L-glutamic acid 5-benzyl ester
5-Benzyl N-Boc-L-glutamate
MFCD00065568
N-t-butoxycarbonyl-L-glutamic acid benzyl ester
B-Glu-BE
Boc-(S)-glutamic acid benzyl ester
(2S)-5-(Benzyloxy)-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-5-oxopentanoic acid
(4S)-5-(Benzyloxy)-4-[(tert-butoxycarbonyl)amino]-5-oxopentanoic acid (non-preferred name)
(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxo-5-phenylmethoxypentanoic acid
Boc-L-Glutamicacid1-benzylester
Boc-Glu(Obzl)-OH
N-Boc-L-glutamic Acid 5-Benzyl Ester
(4S)-5-(Benzyloxy)-4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-5-oxopentanoic acid
N-(tert-Butoxycarbonyl)-L-glutamic Acid 1-Benzyl Ester
N-(tert-Butoxycarbonyl)-L-glutamic acid 5-benzyl ester
Boc-L-Glutamic acid 5-benzylester
Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-(phenylmethyl) ester
N-Boc-L-glutamic Acid 1-Benzyl Ester
1-Benzyl N-(tert-Butoxycarbonyl)-L-glutamate
1-Benzyl N-Boc-L-glutamate
Boc-L-glutamic acid α-benzylester

Biological Activity

[Description]:

Boc-Glu-OBzl is a glutamic acid derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
522.6±50.0 °C at 760 mmHg

[ Melting Point ]:
97 °C

[ Molecular Formula ]:
C₁₇H₂₃NO₆

[ Molecular Weight ]:
337.368

[ Flash Point ]:
269.9±30.1 °C

[ Exact Mass ]:
337.152527

[ PSA ]:
101.93000

[ LogP ]:
3.34

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.524

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Stability and in vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter.

Eur. J. Pharm. Sci. 11 , 43-50, (2000)

One approach to increase drug stability and to facilitate oral absorption of low bioavailability drugs may be to design oligopeptide ester prodrugs which are stable in the gastrointestinal tract, are ...

Side reactions in solid-phase peptide synthesis and their applications.

Int. J. Pept. Protein Res. 48 , 292-298, (1996)

Side reactions in peptide synthesis indicate steps needing improvement as well as opportunities for structural diversification in combinatorial design. Among the side reactions observed in this study,...

Modification of the vitamin K-dependent carboxylase assay.

J. Biochem. Biophys. Methods 11 , 59, (1985)

Methods are presented that describe alternative protocols for the isolation of rat liver microsomes containing the vitamin K-dependent carboxylase and the procedure in which the solubilized enzyme is ...