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PF-184298

Names

[ CAS No. ]:
813447-40-4

[ Name ]:
PF-184298

[Synonym ]:
PZR8DT7L3O
PF-184298
Benzamide, 2,3-dichloro-N-(2-methylpropyl)-N-[(3S)-3-pyrrolidinyl]-
2,3-Dichloro-N-isobutyl-N-[(3S)-3-pyrrolidinyl]benzamide

Biological Activity

[Description]:

PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively; displays good selectivity over dopamine reuptake inhibition (DRI) (IC50=544 nM); possesses good in vitro metabolic stability, weak CYP inhibition and drug-like physicochemical properties consistent with CNS target space.

[References]

References 1. Wakenhut F, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):772. 2. Harrison A, et al. Xenobiotica. 2012 Jan;42(1):57-74. View Related Products by Target Monoamine Transporter

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
461.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H20Cl2N2O

[ Molecular Weight ]:
315.238

[ Flash Point ]:
233.1±28.7 °C

[ Exact Mass ]:
314.095276

[ LogP ]:
3.14

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.574

Related Compounds

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