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14,15-EET

Names

[ CAS No. ]:
81276-03-1

[ Name ]:
14,15-EET

[Synonym ]:
14,15-Epoxyeicosatrienoic acid
14,15-epoxy-5,8,11-eicosatrienoicacid
14,15-EET

Biological Activity

[Description]:

14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590). 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

14,15-Epoxyeicosatrienoic acid (0-10 μM) 促进原代星形胶质细胞培养物中的 Aβ 摄取[1]。

[In Vivo]

14,15-Epoxyeicosatrienoic acid (0.3 mg/kg i.v.) 可抑制小鼠脑小动脉中的血小板聚集[2]。 14,15-Epoxyeicosatrienoic acid (200 ng/ml) 注入海马体可逆转 6 个月大的雄性 FAD 小鼠大脑中的 Aβ 沉积[1]。

[References]

[1]. Chen W, et al. 14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease. J Neurosci. 2020 Oct 14;40(42):8188-8203.  

[2]. Heizer ML, et al. 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. Stroke. 1991 Nov;22(11):1389-93.  

Chemical & Physical Properties

[ Density]:
0.983g/cm3

[ Boiling Point ]:
464.5ºC at 760 mmHg

[ Molecular Formula ]:
C20H32O3

[ Molecular Weight ]:
320.46600

[ Flash Point ]:
155.7ºC

[ Exact Mass ]:
320.23500

[ PSA ]:
49.83000

[ LogP ]:
5.42790

[ Index of Refraction ]:
1.501

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
F,Xi

[ Risk Phrases ]:
11-36/37/38

[ Safety Phrases ]:
16-26-36

[ RIDADR ]:
UN 1170 3/PG 2

Related Compounds