Procaterol hydrochloride

Names

[ Name ]:
Procaterol hydrochloride

[Synonym ]:
2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, hydrochloride (1:1)
MFCD00872222
8-Hydroxy-5-[(1R,2S)-1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinone hydrochloride (1:1)
EINECS 263-763-0
(R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone hydrochloride
rel-8-Hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-Methylethyl)aMino]butyl]-2(1H)-quinolinone Hydrochloride,Hydrate
R*,S*)-(+/-)-8-Hydroxy-5-[1-hydroxy-2-[(1-Methylethyl)aMino]butyl]-2(1H)-quinolinone Monohydrochloride,Hydrat

Biological Activity

[Description]:

Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Inflammation/Immunology

[In Vitro]

Procaterol hydrochloride hemihydrate (0.1 μM，24-72 小时) 抑制人气管上皮细胞中的鼻病毒感染[4]。 Procaterol hydrochloride hemihydrate (0-1 μg/mL, 24/48 h) 抑制 BEAS-2B 细胞中 IL-1β- 和 TNF-α 介导的嗜酸性粒细胞趋化活性[5]。 Procaterol hydrochloride hemihydrate (25-200 nM, 20 h) 保护 16HBE 细胞免受 H2O2 诱导的氧化应激[6]。

[In Vivo]

Procaterol hydrochloride hemihydrate (1、3 或 10 μg/mL，吸入给药) 抑制过敏性炎症豚鼠气道中组胺引起的气流阻塞和微血管渗漏[2]。 Procaterol hydrochloride hemihydrate (0.1 mg/kg，i.p.) 完全消除有意识的豚鼠中 Mch 引起的咳嗽[3]。 Animal Model: Allergic inflammatory guinea-pig model[2] Dosage: 1, 3 or 10 μg/mL Administration: Inhaled administration Result: Inhibited histamine-induced airflow obstruction and microvascular leakage.

[References]

[1]. Tukiainen H, et al. Comparison between oral procaterol and salbutamol in patients with bronchial asthma. Curr Med Res Opin. 1988;11(4):236-41.

[2]. Mirza ZN, et al. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation. Clin Exp Allergy. 1998 May;28(5):644-52.

[3]. Ohkura N, et al. Bronchoconstriction-triggered cough in conscious guinea pigs. Exp Lung Res. 2009 May;35(4):296-306.

[4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44.

[5]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75.

[6]. Deng Z, et al. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50.

Chemical & Physical Properties

[ Boiling Point ]:
559.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₃ClN₂O₃

[ Molecular Weight ]:
326.818

[ Flash Point ]:
291.9ºC

[ Exact Mass ]:
326.139709

[ PSA ]:
85.35000

[ LogP ]:
3.23660

[ Storage condition ]:
Refrigerator, Under Inert Atmosphere

Safety Information

[ HS Code ]:
2933790090

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Related Compounds

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