Zhejiang Hangyu API Co., Ltd
China
Product Name: Procaterol hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Procaterol hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

81262-93-3

81262-93-3 structure

81262-93-3 structure

Name: Procaterol hydrochloride
Chemical Name: Procaterol hydrochloride
CAS Number: 81262-93-3
Molecular Formula: C₁₆H₂₃ClN₂O₃
Molecular Weight: 326.818
Catalog: API Respiratory medication Asthma
Create Date: 2018-08-29 09:20:35
Modify Date: 2024-01-03 09:57:21
Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma[1][2][3].

Name	Procaterol hydrochloride
Synonyms	2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, hydrochloride (1:1) MFCD00872222 8-Hydroxy-5-[(1R,2S)-1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinone hydrochloride (1:1) EINECS 263-763-0 (R,S)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone hydrochloride rel-8-Hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-Methylethyl)aMino]butyl]-2(1H)-quinolinone Hydrochloride,Hydrate R,S)-(+/-)-8-Hydroxy-5-[1-hydroxy-2-[(1-Methylethyl)aMino]butyl]-2(1H)-quinolinone Monohydrochloride,Hydrat

Description	Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vitro	Procaterol hydrochloride hemihydrate (0.1 μM，24-72 小时) 抑制人气管上皮细胞中的鼻病毒感染[4]。 Procaterol hydrochloride hemihydrate (0-1 μg/mL, 24/48 h) 抑制 BEAS-2B 细胞中 IL-1β- 和 TNF-α 介导的嗜酸性粒细胞趋化活性[5]。 Procaterol hydrochloride hemihydrate (25-200 nM, 20 h) 保护 16HBE 细胞免受 H2O2 诱导的氧化应激[6]。
In Vivo	Procaterol hydrochloride hemihydrate (1、3 或 10 μg/mL，吸入给药) 抑制过敏性炎症豚鼠气道中组胺引起的气流阻塞和微血管渗漏[2]。 Procaterol hydrochloride hemihydrate (0.1 mg/kg，i.p.) 完全消除有意识的豚鼠中 Mch 引起的咳嗽[3]。 Animal Model: Allergic inflammatory guinea-pig model[2] Dosage: 1, 3 or 10 μg/mL Administration: Inhaled administration Result: Inhibited histamine-induced airflow obstruction and microvascular leakage.
References	[1]. Tukiainen H, et al. Comparison between oral procaterol and salbutamol in patients with bronchial asthma. Curr Med Res Opin. 1988;11(4):236-41. [2]. Mirza ZN, et al. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation. Clin Exp Allergy. 1998 May;28(5):644-52. [3]. Ohkura N, et al. Bronchoconstriction-triggered cough in conscious guinea pigs. Exp Lung Res. 2009 May;35(4):296-306. [4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [5]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [6]. Deng Z, et al. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50.

Boiling Point	559.1ºC at 760 mmHg
Molecular Formula	C₁₆H₂₃ClN₂O₃
Molecular Weight	326.818
Flash Point	291.9ºC
Exact Mass	326.139709
PSA	85.35000
LogP	3.23660
Storage condition	Refrigerator, Under Inert Atmosphere

HS Code	2933790090

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%