SC 34301

Names

[ Name ]:
SC 34301

[Synonym ]:
Prosta-4,13-dien-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-,methyl ester,(4Z,11alpha,13E)-(+-)

Biological Activity

[Description]:

SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[In Vivo]

SC 34301 (200 µg/kg; p.o.; once a day for three days) 显着减少细菌移位并提高存活率[1]。 Animal Model: BALB/c mice (E. coli, burned)[1] Dosage: 200 µg/kg Administration: P.o.; once a day for three days Result: Significantly reduced the degree of bacterial translocation as measured by blood dpm counts, improved survival rate to 60% in burned mice.

[References]

[1]. Pollak R, et al. A trial of the prostaglandin E1 analogue, enisoprost, to reverse chronic cyclosporine-associated renal dysfunction. Am J Kidney Dis. 1992 Oct;20(4):336-41.

[2]. Fukushima R, et al. The degree of bacterial translocation is a determinant factor for mortality after burn injury and is improved by prostaglandin analogs. Ann Surg. 1992 Oct;216(4):438-44; discussion 444-5.

Chemical & Physical Properties

[ Density]:
1.092g/cm3

[ Boiling Point ]:
490.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₆O₅

[ Molecular Weight ]:
380.51800

[ Flash Point ]:
158.2ºC

[ Exact Mass ]:
380.25600

[ PSA ]:
83.83000

[ LogP ]:
3.72960

[ Index of Refraction ]:
1.536

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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