81026-63-3

81026-63-3 structure

Name: SC 34301
Chemical Name: enisoprost
CAS Number: 81026-63-3
Molecular Formula: C₂₂H₃₆O₅
Molecular Weight: 380.51800
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2018-07-20 19:10:57
Modify Date: 2024-01-07 17:00:22
SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice[1][2].

Name	enisoprost
Synonyms	Prosta-4,13-dien-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-,methyl ester,(4Z,11alpha,13E)-(+-)

Description	SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
In Vivo	SC 34301 (200 µg/kg; p.o.; once a day for three days) 显着减少细菌移位并提高存活率[1]。 Animal Model: BALB/c mice (E. coli, burned)[1] Dosage: 200 µg/kg Administration: P.o.; once a day for three days Result: Significantly reduced the degree of bacterial translocation as measured by blood dpm counts, improved survival rate to 60% in burned mice.
References	[1]. Pollak R, et al. A trial of the prostaglandin E1 analogue, enisoprost, to reverse chronic cyclosporine-associated renal dysfunction. Am J Kidney Dis. 1992 Oct;20(4):336-41. [2]. Fukushima R, et al. The degree of bacterial translocation is a determinant factor for mortality after burn injury and is improved by prostaglandin analogs. Ann Surg. 1992 Oct;216(4):438-44; discussion 444-5.