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4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one

Names

[ CAS No. ]:
809234-33-1

[ Name ]:
4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one

[Synonym ]:
2H-1-Benzopyran-2-one,4-(chloromethyl)-5,7-dihydroxy
4-(chloromethyl)-5,7-dihydroxy-2H-chromen-2-one
4-chloromethyl-5,7-dihydroxycoumarin
4-(chloromethyl)-5,7-dihydroxy-2H-1-benzopyran-2-one
4-chloromethyl-5-hydroxyumbelliferone

Biological Activity

[Description]:

DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

DNA polymerase[1]


[In Vivo]

DNA polymerase-IN-1 (compound 2d)

[References]

[1]. Bruna-Haupt EF, et al. Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents. ACS Omega. 2023 Jul 13;8(29):26479-26496.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H7ClO4

[ Molecular Weight ]:
226.61

[ Exact Mass ]:
226.00300

[ PSA ]:
70.67000

[ LogP ]:
1.94300

Safety Information

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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