Grifolic acid

Names

[ Name ]:
Grifolic acid

[Synonym ]:
2,4-Dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]benzoic acid
Benzoic acid, 2,4-dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-
Grifolic acid

Biological Activity

[Description]:

Grifolic acid is a phenolic compound that is first extracted from the mushroom Albatrellus confluens. Grifolic acid acts as an agonist of the free fatty acid receptor (FFAR4/GPR120)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR120

Research Areas >> Inflammation/Immunology

[In Vitro]

Grifolic acid (2.5-20 µM) treatment reduces RAW264.7 cell viability in a dose and time dependent manner[1].

[References]

[1]. Zhao Y, et al. Grifolic acid induces mitochondrial membrane potential loss and cell death of RAW264.7 macrophages. Mol Med Rep. 2018;17(2):3281-3287.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
557.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₂O₄

[ Molecular Weight ]:
372.498

[ Flash Point ]:
304.8±26.6 °C

[ Exact Mass ]:
372.230072

[ PSA ]:
77.76000

[ LogP ]:
8.22

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.563

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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