Tenacigenin B

Names

[ Name ]:
Tenacigenin B

[Synonym ]:
(3β,5α,11α,12β,14β,17α)-3,11,12-Trihydroxy-8,14-epoxypregnan-20-one
Pregnan-20-one, 8,14-epoxy-3,11,12-trihydroxy-, (3β,5α,11α,12β,14β,17α)-

Biological Activity

[Description]:

Tenacigenin B is a steroid that can be isolated from the genus Alocasia. Tenacigenin B has anti-tumor effects on lymphoma via regulation of Aurora-A[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

[References]

[1]. Peng W, et al. The cytotoxic and tyrosine kinase inhibitory properties of C21 steroids and iridoids from the tubers of Alocasia cucullata. J Nat Med. 2016 Jul;70(3):602-9.

[2]. Dai X, et al. Tenacigenin B Has Anti-Tumor Effect in Lymphoma by In Vitro and In Vivo Study. Med Sci Monit. 2019 Sep 1;25:6563-6573.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
537.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₂O₅

[ Molecular Weight ]:
364.48

[ Flash Point ]:
187.2±23.6 °C

[ Exact Mass ]:
364.224976

[ PSA ]:
90.29000

[ LogP ]:
1.50

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.597

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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