(D-Pro2,D-Trp7·9)-Substance P acetate salt
Names
[ CAS No. ]:
80434-86-2
[ Name ]:
(D-Pro2,D-Trp7·9)-Substance P acetate salt
[Synonym ]:
2-Pro-7,9-Trp-substance p
2-Pro-7,9-Trp-sp
Pttsp
Pt-sp
<D-Pro2,D-Trp7,9>-SP
dt79
[DPro2,DTrp7,9] Substance P
Biological Activity
[Description]:
[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].
[Related Catalog]:
[In Vitro]
[D-Pro2,D-Trp7,9] Substance P decreases proliferation only in a few cell lines, and only in the highest concentration (100 µM). [D-Pro2,D-Trp7,9] Substance P displays a significantly weaker antiproliferative action than Aprepitant (HY-10052) on cancer or normal cell lines[3].
[In Vivo]
[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1]. [D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2]. Animal Model: Adult pigmented rabbits (1.5-3 kg)[1] Dosage: 0.03, 0.3, 3, and 30 nmol Administration: Intravitreal injection or topical application onto the eye, 60 μL Result: Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.
[References]
[1]. Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31.
[2]. Håkanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700.
[3]. Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English.
Chemical & Physical Properties
[ Molecular Formula ]:
C74H106N20O13S
[ Molecular Weight ]:
1515.82000
[ Exact Mass ]:
1514.80000
[ PSA ]:
573.51000
[ LogP ]:
6.76800
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