Boc-NH-O-C1-NHS ester

Names

[ CAS No. ]:
80366-85-4

[ Name ]:
Boc-NH-O-C1-NHS ester

[Synonym ]:
t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester
tBoc-aminooxyacetyl N-hydroxysuccinimide ester
N'-Boc-aminooxyacetyl N-hydroxysuccinimide ester
tBoc-AO-OSu
2-tert-butoxycarbonylaminoxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester

Biological Activity

[Description]:

Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Melting Point ]:
114 °C

[ Molecular Formula ]:
C11H16N2O7

[ Molecular Weight ]:
288.25400

[ Exact Mass ]:
288.09600

[ PSA ]:
114.73000

[ LogP ]:
0.19220

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds